It's apples and oranges. I like the full size Duncan '59 in the neck with a two humbuckers setup and 5 way super switch. I really don't care for the Little '59. To my ears they really aren't that similar. The full size '59 in the neck of my Big Apple Strat almost has a sort of single coil quality to it that just sings, whereas the little one (keep in mind that this is subjective) just doesn't sound right to my ears by comparison. Keep in mind that the little '59 is made to replicate a full size humbucker that was made to replicate old humbuckers. The Heavy Blues 2, on the other hand is a nice hot single coil tone. It is my neck single coil of choice because it is hot, but not muddy, bright, but not overbearing, and is as great for high gain neck pickup soloing as it is for lower gain blues stuff. Oh yeah, and it's hum cancelling.
If it were me, it would be hands down the Heavy Blues 2 if you are going for a hum cancelling single coil tone.