Impossible to answer. Every player, rig and guitar is different so even with the answers limited to two full size humbucker set ups, impossible. Good versatile full size combos I use(d) are (bridge, neck):
AT-1, Bluesbucker (both splitable)
Steve Morse bridge, Breed neck
Super Distortion, Breed neck
Since I do not really like full size humbuckers in the neck spot, one of my favorite combinations is a Duncan Custom 5 in the bridge and a DiMarzio Vintage Mini neck (DP 240) in a telecaster. The wiring is set up for the following combinations: bridge series (for overdriven rock tones), bridge parallel (for the country, chicken pickin' and other clean tones), bridge series + neck (full clean tones), bridge parallel + neck (funky cleans and biting overdriven blues tones), neck (sounds great for both clean and overdriven tones). Very versatile yet easy to operate. I am afraid my playing capabilities and imagination are more limited in versatility than the guitar.
Cheers Stephan