« Reply #1 on: December 21, 2016, 04:17:19 AM »
Mostly the difference is not audible but if you are going to change pickups anyway why not go for an F-spaced one? There are manufacturers that charge the same prices for each (DiMarzio, Bare Knuckle to name a few), and the dimensions are the same - unlike the SD Trembuckers which are a bit larger and may require modification of the pickguard and or the guitar body.
However, if the pickup you want to use in that guitar happens to be a SD a regular spaced model may work without any problems. The low E string is rarely a problem anyway due to its mass. Furthermore, any potential difference from misalignment gets reduced the more overdrive is added.
Cheers Stephan
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