I would say that it depends upon what type of sound you're looking for.. A Cruiser in the bridge of a strat will sound very much like a regular strat bridge pickup with a little more output and girth, and of course noise free as well. The twin blade design will give you great sustain, especially with overdrive, and no drop offs while bending notes.. Might be cool.. What I don't know is whether or not that pickup prefers certain woods over others. I would doubt it though.. And if you use a 250k no-load tone pot you can really experiment with what will work best with that pickup.