If you have the chops you can shred on pretty much anything so the pickups doesnt matter all that much. I also think the amp and pedals are way more important.
But having said that...
Ive never had those two in the same guitar so I cant really say how they fit together but Im not a big fan of the Air Norton, way too muddy, unarticulate and dark for me. The D-Activator is articulate and a bit compressed so its nice to shred on, although I think it shines as metal rhythm pickup and not necessarily on leads.
If I were to come up with some H-H pickup combos for shred Id either go Tone Zone/PAF Pro for a slightly less "super-saturated" tone, or Super Distortion/Super 2 for balls-out, face-melting old-school shred tones.
But thats just me; there are as many preferred pickup combinations as there are guitar players!