[jazzfromhell]

As per the subject. It's a set-neck, mahogany body.
I want the fattest, bassiest pickup that DiMarzio has to offer. My initial reaction is always to go Tone Zone but I don't want to go there in this guitar so I'm thinking Breed.
Music is doomy metal in the Sabbath vein.

Any thoughts or other recommendations?

[dxlxntxxlxr]

Specifically DiMarzio? If I had to go DiMarzio, for what you want, definitely not a tone zone. Maybe a crunch lab or a d sonic. If you want a huge brutal humbucker that retains clarity, BKP warpig. The alnico option is better for doomy Sabbath type stuff but if you want a quicker pickup I'd go ceramic.

[Timius]

Go with the Super Distortion.  It will do the doom stuff.  Wino used to use em before all the doom bands switched to Lace pickups

[daenius]

The D Sonic and the Tone Zone, especially the Tone Zone, will give you that massive dark girth and deep giant bottom end you want for the Sabbath-like and the Doom tones!

[slugworth]

As per the subject. It's a set-neck, mahogany body.
I want the fattest, bassiest pickup that DiMarzio has to offer. My initial reaction is always to go Tone Zone but I don't want to go there in this guitar so I'm thinking Breed.
Music is doomy metal in the Sabbath vein.

Any thoughts or other recommendations?

What you're looking for is the Tone Zone, absolutely.

Breed Bridge is very similar to the Tone Zone except with the EQ hump moved up into the mids.