Surprised that there is no thread on that one - given it was introduced in 2006.
I put it in the neck position of a maple neck/maple board/ash body partscaster strat. Middle pickup is the Injector neck (which was in the neck position before), bridge pickup is a Bareknuckle Holydiver (the closest DiMarzio would probably the AT-1). In #2, the bridge pickup goes to parallel. 500k pots, tone cap is currently a 0.0033uf Orange Drop (subject to change).
Since there is already a detailed thread on the Injector neck I will focus on the difference between that and the HB2.
Output is roughly the same - 170mV vs. 160mV does not matter much really. The balance with the bridge pickup is fine since I like the bridge humbucker to have a bit more output in a HSS set up.
The tone charts (B/M/T) are similar: IN 6/6.5/7, HB2 6/7/6.5, and in that case I would agree that the pickups do not sound vastly different from each other. What is noticeable though is that the HB2 has a bit less highs than the IN and significantly more midrange content. I really like this for overdriven solo tones as it makes the guitar sing better and provides for a good tonal balance with the bridge pickup. It does work well for clean tones, too, provided you can accept that it is warmer than a typical low output vintage strat type pickup - these are really bright, and the HB2 won't give you that sound. The Area 67 would be a better choice in that case.
Now - how does it quack together with the IN in the middle? It does quack well but it's a middier quack, not that super hollow clucky quack of low output singles. Again if you want that, get two Area 67s or an Area 67 for the neck and an Area 58 for the middle.
I have not yet tested the HB2 together with the bridge pickup since the wiring set up in that guitar currently does not provide for that combination. But since I got a spare tone pot that's doing nothing at the moment I may wire it up as a blend control so I can give you an idea of how that works.
Cheers Stephan